Publications
DNA launched suicidal flaviviruses as therapeutic vaccine candidates
Research background
Chronic liver disease, resulting from Hepatitis B virus (HBV), Hepatitis D virus (HDV), or Hepatitis
C virus (HCV) infections, contributes to a major health burden worldwide. The relatively high
cost of the HCV treatment brings concerns about the accessibility, especially in the developing
countries. Hence, there exists a need for cost effect interventions with high efficiency. The use
of DNA prime-viral vector has been validated in prime-boost vaccination. The use of Flavivirus
subgenomic replicons as DNA based vaccine will provide excellent stability and high expression
of the vaccine candidate genes in combination with immune activation…..
Changes in energy metabolism due to acute rotenone-induced mitochondrial complex I dysfunction – An in vivo large animal model.
Abstract Metabolic crisis is a clinical condition primarily affecting patients with inherent mitochondrial dysfunction in situations of augmented energy demand. To model this, ten pigs received an infusion of rotenone, a mitochondrial complex I inhibitor, or vehicle....
Drugs for treatment of colorectal cancer, identified with use of three-dimensional cell culture-based screening, was validated in-vivo by Adlego!
Drugs for treatment of colorectal cancer, identified with use of three-dimensional cell culture-based screening, was validated in-vivo by Adlego. http://www.ncbi.nlm.nih.gov/pubmed/25911689
Mass spectrometry of macromolecules
Data on the use of accelerator mass spectrometry (AMS) in conjunction with in vivo studies of macromolecular drugs are scarce. The present study shows the versatility of this technique when investigating the pharmacokinetics (PK) of a macromolecular drug candidate, a...
Multigene HIV vaccine
It is likely that gene-based vaccines will enter the human vaccine area soon. A few veterinary vaccines employing this concept have already been licensed, and a multitude of clinical trials against infectious diseases or different forms of cancer are ongoing. Highly...
In vivo electroporation
The mechanisms by which in vivo electroporation (EP) improves the potency of i.m. DNA vaccination were characterized by using the hepatitis C virus nonstructural (NS) 3/4A gene. Following a standard i.m. injection of DNA with or without in vivo EP, plasmid levels...
Interesting Reading
The use of Flavivirus subgenomic replicons as DNA based vaccine
Adlego is testing OsteoDex in an in-vivo model of breast cancer!
Adlego is testing OsteoDex in an in-vivo model of breast cancer and you can read more in the link below. https://www.aktietorget.se/NewsItem.aspx?ID=73302
Strong tumor MR contrast enhancement with novel nanomaterial in an oncogene-driven breast cancer model
Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments
PDF-version of this article
AParaDDisE – Anti-Parasitic Drug Discovery in Epigenetics
See website here.
Näsdroppar mot kikhosta väcker intresse
Read the article in Life Sciences Sweden | PDF-version of this article
Dextech testar benskörhetmedicin mot metastaserad prostate cancer
Read the article in Life Sciences Sweden | PDF-version of this article
Immunicum doserar första patienten
Read the article in Life Sciences Sweden | PDF-version of this article